from Wikipedia Cali:
Santiago de Cali (IPA: [sanˈtjaɰo ð̞e ˈkali]), often shortened to Cali, is the main city, municipality and capital of the Valle del Cauca, a department in western Colombia, also known as the Pacific Region. With a population of 2,316.654 hab. Santiago de Cali is the third largest city in Colombia. It is a reference point inside Colombia because of its industrial and commercial development, and has one of the fastest growing economies in the country because of its geographical location. Cali was founded on July 25, 1536 by the Spanish conqueror Sebastián de Belalcázar.
The first part of the name Santiago de Cali honours Saint James the apostle (Santiago in Spanish) whose feast day is celebrated on July 25. There are several possibilities for the origin of the word "Cali". Some attribute it to a mispronunciation of the word "Lili", the name of a local tribe. Others believe that the word "Cali" has Quechua origin, and it was brought by the Yanaconas Indians that came from Quito serving Sebastián de Belalcázar. This theory is reinforced by the fact that near Quito there is an indigenous town named Cali Cali.